When a mutation does not cause a complete loss of function in the wild-type phenotype. © Nature Education.
What are leaky mutations?
A mutant (typically an auxotroph) that results from a partial rather than a complete inactivation of the wild-type function.
What are the mutant types?
Mutations (changes in a gene sequence) can result in mutant alleles that no longer produce the same level or type of active product as the wild-type allele. Any mutant allele can be classified into one of five types: (1) amorph, (2) hypomorph, (3) hypermorph, (4) neomorph, and (5) antimorph.
What causes Hypermorphic mutation?
Hypermorphic alleles are gain of function alleles. A hypermorph can result from an increase in gene dose (a gene duplication), from increased mRNA or protein expression, or constitutive protein activity.
What does Hypermorphic mean?
: a mutant gene having a similar but greater effect than the corresponding wild-type gene.
What is a Hypermorphic mutation?
Hypermorphic Mutation. MGI Glossary. Definition. A type of mutation in which the altered gene product possesses an increased level of activity, or in which the wild-type gene product is expressed at a increased level.